Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.
Cell Experiment | |
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Cell lines | Swiss 3T3 |
Preparation method | Seeding cells in 24-well plates (5000 cells/well) in DMEM/10% FCS. A day later, the medium is changed to DMEM/2% FcS with or without growth factors and tyrphostins are added as indicated. Three days later count the cells in a hemocytometer |
Concentrations | ~50 μM |
Incubation time | 3 days |
Animal Experiment | |
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Animal models | |
Formulation | |
Dosages | |
Administration |
Molecular Weight | 266.29 |
Formula | C16H14N2O2 |
CAS Number | 146535-11-7 |
Solubility (25°C) | DMSO 6 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Hongwei Li, et al. Tyrphostin AG 1296 induces glioblastoma cell apoptosis in vitro and in vivo
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