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Tyrphostin AG 1296

Cat. No. M3097
Tyrphostin AG 1296 Structure
Synonym:

AG 1296

Size Price Availability Quantity
5mg USD 100 In stock
25mg USD 280 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.

Customer Product Validations & Biological Datas
Source Oncol Lett (2015). Figure 2. Tyrphostin AG 1296
Method cell invasion assay
Cell Lines U87MG cells
Concentrations 12.5, 50 or 200 nM
Incubation Time 8 h
Results Statistical analysis demonstrated that the anti.migration effect of tyrphostin AG 1296 in U87MG cells, increased in a dose.dependent manner
Protocol
Cell Experiment
Cell lines Swiss 3T3
Preparation method Seeding cells in 24-well plates (5000 cells/well) in DMEM/10% FCS. A day later, the medium is changed to DMEM/2% FcS with or without growth factors and tyrphostins are added as indicated. Three days later count the cells in a hemocytometer
Concentrations ~50 μM
Incubation time 3 days
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 266.29
Formula C16H14N2O2
CAS Number 146535-11-7
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tyrphostin AG 1296, AG 1296 supplier, VEGFR/PDGFR, inhibitors

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