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Tulobuterol hydrochloride

Cat. No. M13901
Tulobuterol hydrochloride Structure
Synonym:

C-78

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tulobuterol hydrochloride (C-78) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength. Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 264.19
Formula
CAS Number 56776-01-3
Purity >99%
Solubility Water 90 mg/mL
DMSO 50 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Shujuan Luo, et al. Sustained release of tulobuterol from graphene oxide laden hydrogel to manage asthma

[2] Lixia Fu, et al. Tulobuterol patch alleviates allergic asthmic inflammation by blockade of Syk and NF-κB activation in mice

[3] Yuichi Takizawa, et al. Skin permeability of tulobuterol in two transdermal formulations and their followability

[4] Mutsuo Yamaya, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells

[5] Gen Tamura, et al. Transdermal tulobuterol patch, a long-actingβ(2)-agonist

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Keywords: Tulobuterol hydrochloride, C-78 supplier, Adrenergic Receptor, inhibitors

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