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Trimebutine

Cat. No. M6035
Trimebutine Structure
Synonym:

Mebutin

Size Price Availability Quantity
50mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 387.47
Formula C22H29NO5
CAS Number 39133-31-8
Purity >99%
Solubility 50 mg/mL in DMSO
Storage at -20°C
References

Comparative efficacy and safety of trimebutine versus mebeverine in the treatment of irritable bowel syndrome.
Rahman MZ, et al. Mymensingh Med J. 2014 Jan;23(1):105-13. PMID: 24584382.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Trimebutine, Mebutin supplier, Opioid Receptor, inhibitors

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