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Trimebutine maleate

Cat. No. M6036
Trimebutine maleate Structure
Size Price Availability Quantity
500mg USD 70 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 503.54
Formula C26H33NO9
CAS Number 34140-59-5
Purity >99%
Solubility 38 mg/mL in DMSO
Storage at -20°C
References

Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.
Long Y, et al. Eur J Pharmacol. 2010 Jun 25;636(1-3):159-65. PMID: 20371236.

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  Catalog
Abmole Inhibitor Catalog 2017




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