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Triapine

Cat. No. M3084
Triapine Structure
Synonym:

3-AP

Size Price Availability
25mg USD 190 Custom Synthesis
100mg USD 550 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis.

Protocol
Cell Experiment
Cell lines Wild-type KB and HU-resistant KB nasopharyngeal carcinoma cells.
Preparation method Plating cells at a density of 104 cells/mL per well in 24-well plates. Adding drugs to cells and incubations are continued for a period of 3 generations (untreated control cells), followed by assessment of cell growth by the methylene blue assay.
Concentrations ~10 μM
Incubation time A period of 3 generations
Animal Experiment
Animal models BALB/cBA/2 (CD2F1) mice with the L1210 leukemia and the M109 lung carcinoma, athymic nu/nu mice with the human A2780 ovarian carcinoma xenograft.
Formulation 0.9% NaCl or water
Dosages ~24 mg/kg
Administration i.p. or i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 195.24
Formula C7H9N5S
CAS Number 200933-27-3
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Triapine, 3-AP supplier, DNA/RNA Synthesis, inhibitors

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