Triadimenol (Triademenol) is a triazole-type fungicide that was identified as weak estrogen receptor agonists, Triademenol is reported as a potent exosome inhibitor which can block the activity of exosomes.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 120 mg/L|
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.
Datta A, et al. Sci Rep. 2018 May 25;8(1):8161. PMID: 29802284.
Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.
Kenneke JF, et al. Chem Res Toxicol. 2008 Oct;21(10):1997-2004. PMID: 18763812.
Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives.
Menegola E, et al. Toxicol In Vitro. 2005 Sep;19(6):737-48. PMID: 15913947.
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Cefquinome sulfate is a broad-spectrum fourth-generation cephalosporin antibiotic.
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Nifuratel is a local antiprotozoal and antifungal agent used in gynecology.
Piroctone Olamine is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff, fungal infections.
Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections, Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.
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