Triadimenol (Triademenol) is a triazole-type fungicide that was identified as weak estrogen receptor agonists, Triademenol is reported as a potent exosome inhibitor which can block the activity of exosomes.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 120 mg/L|
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.
Datta A, et al. Sci Rep. 2018 May 25;8(1):8161. PMID: 29802284.
Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.
Kenneke JF, et al. Chem Res Toxicol. 2008 Oct;21(10):1997-2004. PMID: 18763812.
Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives.
Menegola E, et al. Toxicol In Vitro. 2005 Sep;19(6):737-48. PMID: 15913947.
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Bedaquiline, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
Sodium Houttuyfonate is the active compound of the Houttuynia plant.
Thimerosal inhibits a wide range of thiol-dependent enzymes and proteins, such as PI3-kinase-dependent methionine synthetase, glutamate transport receptor, and Na++K+ dependence ATPase.
|Blasticidin S hydrochloride
Blasticidin S HCl is a potent inhibitor of protein synthesis in both prokaryotic and eukaryotic cells. Blasticidin S hydrochloride is a nucleoside antibiotic isolated from Streptomyces griseochromogenes.
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