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Triadimenol

Cat. No. M8981
Triadimenol Structure
Synonym:

Triademenol; TOL

Size Price Availability Quantity
20mg USD 240 In stock
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Quality Control
  • Current batch:
  • Purity >96%
  • COA
  • MSDS
Biological Activity

Triadimenol (Triademenol) is a triazole-type fungicide that was identified as weak estrogen receptor agonists, Triademenol is reported as a potent exosome inhibitor which can block the activity of exosomes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 295.76
Formula C14H18ClN3O2
CAS Number 55219-65-3
Purity >96%
Solubility Water 120 mg/L
Storage at -20°C
References

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.
Datta A, et al. Sci Rep. 2018 May 25;8(1):8161. PMID: 29802284.

Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.
Kenneke JF, et al. Chem Res Toxicol. 2008 Oct;21(10):1997-2004. PMID: 18763812.

Study on the common teratogenic pathway elicited by the fungicides triazole-derivatives.
Menegola E, et al. Toxicol In Vitro. 2005 Sep;19(6):737-48. PMID: 15913947.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Triadimenol, Triademenol; TOL supplier, Anti-infection, inhibitors

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