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Tosufloxacin tosylate hydrate

Cat. No. M10404
Tosufloxacin tosylate hydrate Structure
Synonym:

A-61827; T-3262 tosylate hydrate

Size Price Availability Quantity
100mg USD 40  USD40 In stock
500mg USD 80  USD80 In stock
1g USD 100  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tosufloxacin tosylate hydrate is a fluoroquinolone antibacterial agent used to treat susceptible infections.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 594.56
Formula C19H15F3N4O3.C7H8O3S.H2O
CAS Number 1400591-39-0
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Nobuyuki Takahashi, et al. J Pharm Health Care Sci. Effect of xanthan gum-based food thickeners on the dissolution profile of fluoroquinolones oral formulations

[2] A L Barry, et al. J Antimicrob Chemother. In-vitro activities of temafloxacin, tosufloxacin (A-61827) and five other fluoroquinolone agents

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Keywords: Tosufloxacin tosylate hydrate, A-61827; T-3262 tosylate hydrate supplier, Antibiotic, inhibitors

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