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Tiotropium Bromide

Cat. No. M6016
Tiotropium Bromide   Structure
Synonym:

Tiopropium

Size Price Availability Quantity
50mg USD 120 In stock
100mg USD 220 In stock
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Quality Control
Biological Activity

Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 472.42
Formula C19H22BrNO4S2
CAS Number 136310-93-5
Purity 99.40%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.
Bosnjak B, et al. Pulm Pharmacol Ther. 2014 Feb;27(1):44-51. PMID: 24090641.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tiotropium Bromide , Tiopropium supplier, AChR/AChE, inhibitors

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