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Tianeptine sodium salt

Cat. No. M5044
Tianeptine sodium salt Structure
Size Price Availability Quantity
10mM*1mL USD 90  USD90 In stock
10mg USD 80  USD80 In stock
50mg USD 250  USD250 In stock
100mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

Tianeptine blocks the stress-induced suppression of PB potentiation in CA1 without affecting the stress-induced enhancement of LTP in basolateral nucleus (BLA) of the amygdala in anesthetized rats. Tianeptine administered under non-stress conditions enhances PB potentiation in the hippocampus and LTP in the amygdala in anesthetized rats.Tianeptine results in a normalized scaling of the amplitude ratio of NMDA receptor to AMPA/kainate receptor-mediated currents and prevents the stress-induced attenuation of NMDA-EPSCs deactivation in rats.

Chemical Information
Molecular Weight 458.93
Formula C21H24ClN2NaO4S
CAS Number 30123-17-2
Solubility (25°C) DMSO 91 mg/mL
Water 91 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vouimba RM,et.al. Stress. Differential effects of predator stress and the antidepressant tianeptine on physiological plasticity in the hippocampus and basolateral amygdala.

[2] Castanon N,et.al. Psychopharmacology (Berl). Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1beta in the rat.

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