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Tiagabine

Cat. No. M6009
Tiagabine Structure
Synonym:

Gabitril, NO050328, NO328, TGB

Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 130 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 375.55
Formula C20H25NO2S2
CAS Number 115103-54-3
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effects of γ-Aminobutyric acid transporter 1 inhibition by tiagabine on brain glutamate and γ-Aminobutyric acid metabolism in the anesthetized rat In vivo.
Patel AB, et al. J Neurosci Res. 2015 Jul;93(7):1101-8. PMID: 25663257.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tiagabine, Gabitril, NO050328, NO328, TGB supplier, GABA Receptor, inhibitors

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