Catalog

GABA Receptor GABA Receptor

Inhibitors

Cat.No.	Name	Information
M10326	Zuranolone	Zuranolone also known as SAGE-217, is a potent GABAA receptor agonist with EC50 values of 296 nM and 163 nM for α1β2γ2 and α4β3δ GABAA receptors.
M9874	SSD114 hydrochloride	SSD114 hydrochloride is a GABA_B receptor positive allosteric modulator.
M9856	Pipequaline	Pipequaline (PK-8165) is a partial benzodiazepine receptor agonist with anxiolytic activity.
M9411	AZD-7325	AZD-7325 is a GABA-Aα2,3 -selective receptor modulator.
M9127	ONO-8590580	ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.
M9114	LAU159	LAU159 is a potent, functionally selective α6β3γ2 GABAA receptor modulator.
M8879	AOA hemihydrochloride	Aminooxyacetic acid hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
M8027	5α-Pregnan-3α-ol-20-one	Positive allosteric modulator of GABA_A chloride channel.
M7691	Chlormethiazole hydrochloride	Chlormethiazole hydrochloride is a GABA_A agonist; glycine receptor modulator.
M6195	Propofol	Propofol inhibited tumor size, cell viability and promoted cell apoptosis via inhibiting mTOR/p70S6K pathway mediated by HOTAIR in cervical cancer.
M6010	Tiagabine HCl	Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
M6009	Tiagabine	Tiagabine is an anti-convulsive medication and a selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
M5870	Pentylenetetrazol	Pentylenetetrazol displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GABA(A) receptor antagonist.
M5730	L-Cycloserine	L-cycloserine irreversibly inhibit GABA pyridoxal 5′-phosphate-dependent aminitransferase in E. coli, as well in the brains of various animals in a time-dependent manner, results in increased levels of gamma-aminobutyric acid (GABA), which is an inhibitory neurotransmitter in vivo.
M5669	Gabapentin HCl	Gabapentin HCl is a GABA analogue, used to treat seizures and neuropathic pain.
M5653	Flumazenil	Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
M5575	Dihydroergotoxine mesylate	Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.
M5442	Baclofen	Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant.
M5390	Afloqualone	Afloqualone is a agonist of GABA receptor .
M5378	Acamprosate calcium	Acamprosate calcium (Campral EC) is a GABA receptor agonist and glutamate system modulator.
M4815	Vigabatrin	Vigabatrin is a selective GABA-T (transaminase) inhibitor.
M3981	Bilobalide	Bilobalide, a natural product extracted from Ginkgo biloba leaf, is known to exhibit a number of pharmacological activities.
M3968	Dihydromyricetin	Dihydromyricetin is a natural antioxidant flavonoid from Ampelopsis grossedentata.
M3938	Baicalin	Baicalin is a known prolyl endopeptidase inhibitor that induces apoptosis in pancreatic cancer cells.
M3600	Gabapentin	Gabapentin is a pharmaceutical agent, specifically a GABA analogue.
M3344	Nefiracetam	Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions.
M2555	AWD 131-138	AWD 131-138 is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models.
M2347	(+)-Bicuculline	(+)-Bicuculline is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
M2005	(R)-Baclofen	(R)-baclofen is a selective gamma-aminobutyric acid(B) agonist.
M1952	Methionine	Methionine is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
M1893	Etomidate	Etomidate (marketed as Amidate) is a general anesthetic with GABA modulatory and GABA-mimetic actions.
M1891	SKF 89976A hydrochloride	SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1.

Signaling Pathways

Product Type

GABA Receptor GABA Receptor

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