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Thrombin

Cat. No. M9804
Thrombin Structure
Size Price Availability Quantity
500ug USD 120 In stock
1mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity Activity: >2000 U/mg protein
  • COA
  • MSDS
Biological Activity

Thrombin is a trypsin-like allosteric serine protease. Thrombin enables site-specific cleavage of fusion proteins with an accessible Thrombin recognition sequence and can be used to digest GST-tagged proteins.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number 9002-04-4
Purity Activity: >2000 U/mg protein
Solubility Water ≥ 5 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus
Valery Golderman, et al. J Mol Neurosci. 2019 Feb;67(2):227-234. PMID: 30515700.

The Importance of Thrombin in Cerebral Injury and Disease
Harald Krenzlin, et al. Int J Mol Sci. 2016 Jan 11;17(1):84. PMID: 26761005.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Thrombin supplier, inhibitors

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