Thiazolidinediones (TZDs), such as rosiglitazone (RSG) and pioglitazone, are antidiabetic drugs that improve glycemia by decreasing insulin resistance through the binding and activation of the peroxisome proliferator-activated receptor γ. Some TZDs might may also affect the activity of the γ isoform of PPAR. These receptors modulate the expression of genes involved in glucose and lipid metabolism, insulin signal transduction, inflammation and cell differentiation.
| Molecular Weight | 89.16 |
| Formula | C3H7NS |
| CAS Number | 504-78-9 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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DSO-5a is a potent, selective, orally active BB3 agonist. |
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Carfloglitazar sodium is a dual agonist of the pan peroxisome proliferator-activated receptor (PPARα/γ) with EC50 values of 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ, respectively.It can be used in studies related to nonalcoholic steatohepatitis (NASH). |
| Seladelpar
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| 4'-O-Methylhonokiol
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| 3-Phenyl-2-propen-1-ol
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. |
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