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Thiazolidinediones (TZDs), such as rosiglitazone (RSG) and pioglitazone, are antidiabetic drugs that improve glycemia by decreasing insulin resistance through the binding and activation of the peroxisome proliferator-activated receptor γ. Some TZDs might may also affect the activity of the γ isoform of PPAR. These receptors modulate the expression of genes involved in glucose and lipid metabolism, insulin signal transduction, inflammation and cell differentiation.
| Molecular Weight | 89.16 |
| Formula | C3H7NS |
| CAS Number | 504-78-9 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| GQ-16
GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. |
| SR10221
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. |
| Amorfrutin B
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. |
| Netoglitazone
Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity. |
| DSO-5a
DSO-5a is a potent, selective, orally active BB3 agonist. |
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