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Theaflavin is a natural influenza A (H1N1) neuraminidase inhibitor. Theaflavin is a polyphenolic flavonoid that has been found in black tea and has diverse biological activities, including antioxidant, anticancer, anti-inflammatory, and antiviral properties.
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Source | PLoS One (2015). Figure 3. Theaflavin |
| Method | black tea extract | |
| Cell Lines | epithelial cells | |
| Concentrations | 50 and 200 μg/ml | |
| Incubation Time | 48 h | |
| Results | While theaflavin did not induce the secretion of significant amounts of hBDs by oral epithelial cells, theaflavin-3,3’-digallate at 75 μg/ml and 100 μg/ml was able to significantly induce the secretion of hBD-1 and hBD-2. |
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Source | PLoS One (2015). Figure 2. Theaflavin |
| Method | black tea extract | |
| Cell Lines | epithelial cells | |
| Concentrations | 50 and 200 μg/ml | |
| Incubation Time | 48 h | |
| Results | More specifically, the black tea extract (200 μg/ml), as well as theaflavin and theaflavin-3,3’-digallate (50 μg/ml) reduced IL-8 secretion by 85%, 79%, and 86%, respectively. |
| Cell Experiment | |
|---|---|
| Cell lines | OBA-9 cells |
| Preparation method | OBA-9 cells were treated with the black tea extract (150 and 200 μg/ml), theaflavin (75 and 100 μg/ml), theaflavin-3,3’-digallate (75 and 100 μg/ml) or EGCG (100 μg/ml) for 48 h at 37°C in a 5% CO2 atmosphere. Following stimulation, the supernatants were collected, centrifuged (500 x g for 5 min) and stored at -80°C until used. |
| Concentrations | 75 and 100 μg/ml |
| Incubation time | 48 h |
| Animal Experiment | |
|---|---|
| Animal models | nude mice |
| Formulation | PBS |
| Dosages | 10 mg/kg/d |
| Administration | i.v. |
| Molecular Weight | 564.49 |
| Formula | C29H24O12 |
| CAS Number | 4670-05-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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