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Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers. Thalidomide inhibits E3 ubiquitin ligase, a CrBN-DDB1-Cul4A complex.
Brain Behav Immun. 2022 Feb 7;102:23-39.
Spinal microglia-derived TNF promotes the astrocytic JNK/CXCL1 pathway activation in a mouse model of burn pain
Thalidomide purchased from AbMole
Biomed Pharmacother. 2021 Sep;141:111876.
Cudraxanthone L inhibits gastric cancer by regulating the MAPK signalling and promoting FAS-mediated pathway
Thalidomide purchased from AbMole
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 258.23 |
| Formula | C13H10N2O4 |
| CAS Number | 50-35-1 |
| Purity | >98% |
| Solubility | DMSO 30 mg/mL |
| Storage | at -20°C |
[1] Takumi Ito, et al. Molecular mechanisms of thalidomide and its derivatives
[2] James E Ridings. The thalidomide disaster, lessons from the past
[3] Michael E Franks, et al. Thalidomide
[4] E Laffitte, et al. Thalidomide
[5] R J D'Amato, et al. Thalidomide is an inhibitor of angiogenesis
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