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Synonym: Thalomid
Thalidomide is an immunomodulatory compound and the prototype of the thalidomide class of drugs. Thalidomide inhibits TNFα production by stimulated human monocytes and induces monocyte apoptosis. Thalidomide costimulates primary human T lymphocytes and inhibits angiogenesis.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 258.23 |
| Formula | C13H10N2O4 |
| CAS Number | 50-35-1 |
| Purity | >99% |
| Solubility | DMSO 40 mg/mL |
| Storage | at -20°C |
| Related TNF-alpha Products |
|---|
| Lenalidomide hemihydrate
Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM. |
| Acetylcysteine
Acetylcysteine(N-acetyl-l-cysteine) is a ROS(reactive oxygen species) inhibitor that antagonizes the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. |
| Bioymifi
Bioymifi, a small-molecule death receptor 5 (DR5) agonist, binds to the extracellular domain(ECD) of DR5 with a Kd of 1.2 μM but showed little binding affinity to the DR4 ECD. It induces DR5 clustering and aggregation, leading to apoptosis. |
| GSK481
GSK481 is a highly potent and monoselective Receptor Interacting Protein 1 kinase inhibitor. |
| Necrostatin-1
Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. |
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