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TG4-155

Cat. No. M9277
TG4-155 Structure
Size Price Availability Quantity
10mM*1mL USD 85.5  USD95 In stock
5mg USD 79.2  USD88 In stock
10mg USD 130.5  USD145 In stock
25mg USD 261  USD290 In stock
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Quality Control
Biological Activity

TG4-155 is a brain penetrant EP2 antagonist (KB = 2.4 nM) that is over 1000-fold less effective at EP4 (KB = 11.4 µM) and a panel of other receptors and channels. TG4-155 crosses the blood brain barrier, and has no antagonistic effects on EP4 signaling, and displays neuroprotective effects in a pilocarpine-induced status epilepticus (SE) seizure model. TG4-155 significantly reduces neurodegeneration in a mouse model of status epilepticus, induced by pilocarpine.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 394.46
Formula C23H26N2O4
CAS Number 1164462-05-8
Purity 99.89%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Prostanoid receptor EP2 as a therapeutic target.
Ganesh T. J Med Chem. 2014 Jun 12;57(11):4454-65. PMID: 24279689.

Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.
Jiang J, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):360-7. PMID: 23192657.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TG4-155 supplier, Prostaglandin Receptor, inhibitors

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