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Testosterone Enanthate

Cat. No. M6119
Testosterone Enanthate Structure
Size Price Availability Quantity
25mg USD 80 In stock
50mg USD 120 In stock
100mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

We have demonstrated, to the best of our knowledge for the first time, the effects of short (1-day) and prolonged (2-weeks, 10-weeks) in vivo administrations of testosterone enanthate (TE) on molecular markers of pituitary functionality as well as prolactin (PRL) and cAMP signaling in Leydig cells.

Protocol
Cell Experiment
Cell lines Leydig cells
Preparation method For in vitro experiments the primary cultures of purified Leydig cells were isolated from undisturbed rats and plated for monitoring genes expression. After 2 h of recovery, the culture medium was trashed and the Leydig cells were incubated for 20 h without (CUT, untreated (control) cells) or with test osterone (T, 20 μM ) or cyproterone-acetate (CPA, 100 μM ) or combination CPA (100 μM ) + T (20 μM ), or in presence of hCG (5 192 and 50 ng/ml) as a positive control.
Concentrations 20 μM
Incubation time 20 h
Animal Experiment
Animal models male Wistar rats
Formulation
Dosages 0.5mg/100g or 2.5 mg/100g
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 400.59
Formula C26H40O3
CAS Number 315-37-7
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats.
Bjelic MM, et al. J Steroid Biochem Mol Biol. 2015 May;149:58-69. PMID: 25603467.

Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor.
Bjelic MM, et al. Mol Cell Endocrinol. 2014 Oct;396(1-2):10-25. PMID: 25153259.

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