Subcutaneous etonogestrel implants in combination with injectable testosterone decanoate resulted in profound suppression of spermatogenesis that could be maintained for up to 1 year.
|Animal models||male B/W mice|
|Dosages||10 and 40 mg/kg|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
An analysis of the influence of sex hormones on Balb/c mice infected with Plasmodium berghei.
Lopes LN, et al. Microb Pathog. 2016 Jan;90:7-12. PMID: 26549492.
Detectability of testosterone esters and estradiol benzoate in bovine hair and plasma following pour-on treatment.
Stolker AA, et al. Anal Bioanal Chem. 2009 Oct;395(4):1075-87. PMID: 19705109.
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