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TCS PrP Inhibitor 13 is a antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.
| Molecular Weight | 281.27 |
| Formula | C15H11N3O3 |
| CAS Number | 34320-83-7 |
| Solubility (25°C) | DMSO 28.13 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Gobeil, et al. Hypertension. Structure-activity studies of B1 receptor related peptide.
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