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TC OT 39 

Cat. No. M30147
TC OT 39  Structure
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Biological Activity

TC OT 39 is a synthetic oxytocin analog, as well as a selective agonist of oxytocin receptor (OXTR, EC50=180 nM). TC OT 39 is also an Avprla vasopressin receptor antagonist with an Ki value of 330 nM. TC OT 39 exhibits sedative effects in mouse models.

Chemical Information
Molecular Weight 600.78
Formula C32H40N8O2S
CAS Number 479232-57-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ileana De Anda-Duran, et al. Neurology. Carotid Intima-Media Thickness and Midlife Cognitive Function: Impact of Race and Social Disparities in the Bogalusa Heart Study

[2] Jori A Leijdekkers, et al. Hum Reprod. Cumulative live birth rates in low-prognosis women

[3] Sheryl S Moy, et al. Neuropharmacology. Prosocial effects of an oxytocin metabolite, but not synthetic oxytocin receptor agonists, in a mouse model of autism

[4] Anna Kawińska-Hamala, et al. Endokrynol Pol. Correlations between 10-year risk of death from cardiovascular diseases

[5] Wen-Rong Wan, et al. Zhongguo Zhen Jiu. [Post-stroke shoulder-hand syndrome treated with acupuncture and rehabilitation: a randomized controlled trial]

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Keywords: TC OT 39  supplier, Oxytocin Receptor, inhibitors, activators

 
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