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Taxiphyllin

Cat. No. M17300
Taxiphyllin Structure
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Biological Activity

Taxiphyllin

Chemical Information
CAS Number 21401-21-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guillermo F Padilla-Gonzlez, et al. J Agric Food Chem. Cyanogenic Derivatives as Chemical Markers for the Authentication of Commercial Products of Bamboo Shoots

[2] Katrin Luck, et al. Plant Mol Biol. CYP79 P450 monooxygenases in gymnosperms: CYP79A118 is associated with the formation of taxiphyllin in Taxus baccata

[3] Mamdouh Nabil Samy, et al. Chem Pharm Bull (Tokyo). Taxiphyllin 6'-O-gallate, actinidioionoside 6'-O-gallate and myricetrin 2″-O-sulfate from the leaves of Syzygium samarangense and their biological activities

[4] Poonam Singhal, et al. Crit Rev Food Sci Nutr. Bamboo shoots: a novel source of nutrition and medicine

[5] A J Cutler, et al. J Biol Chem. The in vitro biosynthesis of taxiphyllin and the channeling of intermediates in Triglochin maritima

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