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Tarloxotinib bromide

Cat. No. M9686
Tarloxotinib bromide Structure
Synonym:

TH-4000; PR-610

Size Price Availability
5mg USD 450  USD450 4-7 Days
10mg USD 748  USD748 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor. Tarloxotinib has the potential to effectively shut down aberrant EGFR signaling in a tumor-selective manner, thus potentially avoiding or reducing the systemic side effects associated with currently available EGFR tyrosine kinase inhibitors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 681.77
Formula C24H24Br2ClN9O3
CAS Number 1636180-98-7
Purity >98%
Solubility DMSO ≥ 28 mg/mL
Storage at -20°C
References

[1] Julia K Harms, et al. Impact of Tumour Hypoxia on Evofosfamide Sensitivity in Head and Neck Squamous Cell Carcinoma Patient-Derived Xenograft Models

[2] Stephen Mf Jamieson, et al. Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma

[3] Ahmed Salem, et al. Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome

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  Catalog
Abmole Inhibitor Catalog




Keywords: Tarloxotinib bromide, TH-4000; PR-610 supplier, EGFR/HER2, inhibitors

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