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Tamoxifen Citrate (ICI 46474)

Cat. No. M2280
Tamoxifen Citrate (ICI 46474) Structure
Synonym:

ICI 46474; Istubal; Nolvadex

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 55  USD55 In stock
100mg USD 40  USD40 In stock
500mg USD 60  USD60 In stock
1g USD 80  USD80 In stock
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Quality Control
Biological Activity

Tamoxifen Citrate (Nolvadex) is an estrogen receptor antagonist with an IC50 of 31 μM for the MCF-7 cells. In some tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 563.64
Formula C26H29NO.C6H8O7
CAS Number 54965-24-1
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Turgut Karaca, et al. Int J Surg. Effects of tamoxifen citrate on postoperative intra-abdominal adhesion in a rat model

[2] V Hug, et al. J Clin Oncol. Tamoxifen-citrate counteracts the antitumor effects of cytotoxic drugs in vitro

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tamoxifen Citrate (ICI 46474), ICI 46474; Istubal; Nolvadex supplier, Estrogen Receptor, inhibitors

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