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TAK-700

Cat. No. M3750

TAK-700 Structure

Synonym: Orteronel

Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 230 In stock
50mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

TAK-700 (Orteronel) selectively inhibits the enzyme CYP17A1 which is expressed in testicular, adrenal, and prostatic tumor tissues. 17,20-Lyase inhibition by orteronel was tolerable and results in declines in PSA and testosterone, with evidence of radiographic responses.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Adult male cynomolgus monkeys.
Formulation TAK-700 is dissolved in 0.5% methylcellulose.
Dosages ≤1 mg/kg
Administration Administered via p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 307.35
Formula C18H17N3O2
CAS Number 566939-85-3
Purity >99%
Solubility DMSO ≥60 mg/mL
Ethanol ≥60 mg/mL
Storage at -20°C
References

Phase I/II trial of orteronel (TAK-700)--an investigational 17,20-lyase inhibitor--in patients with metastatic castration-resistant prostate cancer.
Dreicer R, et al. Clin Cancer Res. 2014 Mar 1;20(5):1335-44. PMID: 24418642.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: TAK-700, Orteronel supplier, Androgen Receptor, inhibitors

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