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(+/-)-Sulfinpyrazone

Cat. No. M5351
(+/-)-Sulfinpyrazone Structure
Size Price Availability Quantity
100mg USD 70 In stock
500mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sulfinpyrazone exerts significant electrophysiologic actions under various experimental conditions. It raises the ventricular fibrillation threshold as well as the mid diastolic threshold and prolongs the effective refractory period. In the acutely ischemic heart, it attenuates the effect of coronary occlusion on the ventricular fibrillation threshold but has no effect after reperfusion. A protective influence of the drug is also evident during sympathetic humoral stimulation with norepinephrine. The antifibrillatory effect of sulfinpyrazone is additive to the changes elicited by beta adrenergic blockade with practolol or cardiac membrane stabilization with lidocaine.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 404.48
Formula C23H20N2O3S
CAS Number 57-96-5
Purity >99%
Solubility 80 mg/mL in DMSO
Storage at -20°C
References

Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolites.
He M, et al. Drug Metab Dispos. 1995 Jun;23(6):659-63. PMID: 7587949.

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  Catalog
Abmole Inhibitor Catalog 2017




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