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Stiripentol

Cat. No. M8186
Stiripentol Structure
Synonym:

BCX2600

Size Price Availability Quantity
10mg USD 86  USD86 In stock
25mg USD 164  USD164 In stock
50mg USD 220  USD220 In stock
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Quality Control
Biological Activity

Stiripentol can be used in the third generation of anti-epileptic studies that enhance gabaergic neurotransmission. Due to its inhibition of several cytochrome P450 enzymes, it has a wide range of pharmacokinetic interactions. Stiripentol also has neuroprotective effects, reducing calcium-mediated neurotoxicity. Stiripentol is also a compound used to study inhibition of neuronal LDH-5 isozyme activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 234.29
Formula C14H18O3
CAS Number 49763-96-4
Purity 99.92%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

[1] No authors listed. Med Lett Drugs Ther. Stiripentol (Diacomit) for Dravet syndrome

[2] No authors listed. Aust Prescr. Stiripentol for Dravet syndrome

[3] No authors listed. Stiripentol

[4] James E Frampton. Stiripentol: A Review in Dravet Syndrome

[5] No authors listed. Stiripentol

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Abmole Inhibitor Catalog




Keywords: Stiripentol, BCX2600 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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