Free shipping on all orders over $ 500

Stiripentol

Cat. No. M8186
Stiripentol Structure
Synonym:

BCX2600

Size Price Availability Quantity
10mg USD 86  USD86 In stock
25mg USD 164  USD164 In stock
50mg USD 220  USD220 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Stiripentol is an LDH inhibitor. Stiripentol (300 mg/kg ip) had a small effect on high-voltage spikes in the kainate model. Stiripentol (500 mM) inhibited the lactate-to-pyruvate conversion as well as the pyruvate-to-lactate conversion by both human LDHs. Lineweaver-Burk plots revealed that the inhibition by stiripentol was noncompetitive, suggesting that stiripentol binds to the LDHs at a different site with lactate and pyruvate.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 234.29
Formula C14H18O3
CAS Number 49763-96-4
Purity 99.92%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
Related Cytochrome P450 (e.g. CYP17) Products
Bergaptol

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.

ε-​Viniferin

ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM.

Rhapontigenin

Rhapontigenin is a selective inactivator of cytochrome P450 1A1 with IC50 of 400 nM.

(Rac)-Brassinazole

(Rac)-Brassinazole is a brassinosteroid (BR) biosynthesis inhibitor.

Apigenin

Apigenin is a protein kinase inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Stiripentol, BCX2600 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.