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Steviol

Cat. No. M16539
Steviol Structure
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Biological Activity

Steviol

Chemical Information
CAS Number 471-80-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuqi Li, et al. Food Funct. The role of metabolites of steviol glycosides and their glucosylated derivatives against diabetes-related metabolic disorders

[2] Xuan Zhou, et al. Appl Microbiol Biotechnol. Metabolic engineering for the synthesis of steviol glycosides: current status and future prospects

[3] Marta Libik-Konieczny, et al. Appl Microbiol Biotechnol. Synthesis and production of steviol glycosides: recent research trends and perspectives

[4] Hui-Ling Jiang, et al. J Asian Nat Prod Res. Bioconversion of steviol glycosides into steviol by Microbacterium barkeri

[5] Amir Abbas Momtazi-Borojeni, et al. Curr Pharm Des. A Review on the Pharmacology and Toxicology of Steviol Glycosides Extracted from Stevia rebaudiana

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