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Stearyl gallate

Cat. No. M38766
Stearyl gallate Structure
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Biological Activity

Stearyl gallate is an alkyl gallate with a long alkyl chain (carbon number of 18). Stearyl gallate has an antioxidant activity, and a weak antiviral activity against HSV-1.

Chemical Information
Molecular Weight 422.6
Formula C25H42O5
CAS Number 10361-12-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chengyu Jiang et al. Antioxidants (Basel). Identification and Antioxidant Abilities of Enzymatic-Transesterification (-)-Epigallocatechin-3- O-gallate Stearyl Derivatives in Non-Aqueous Systems

[2] Eisuke Takai et al. J Biochem. Effects of alkyl chain length of gallate on self-association and membrane binding

[3] H Sakagami et al. Anticancer Res. Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis

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