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SR9243

Cat. No. M4874

SR9243 Structure
Size Price Availability Quantity
5mg USD 65 In stock
10mg USD 90 In stock
50mg USD 270 In stock
100mg USD 455 In stock
200mg USD 725 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 626.62
Formula C31H32BrNO4S2
CAS Number 1613028-81-1
Purity >99%
Solubility DMSO <1 mg/mL
Water <1 mg/mL
Storage at -20°C
References

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
Flaveny CA, et.al. Cancer Cell. 2015 Jul 13;28(1):42-56. PMID: 26120082.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SR9243 supplier, Liver X Receptor, inhibitors

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