In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments.
|Source||Biomed Res Int (2018). Figure 1. SR9243|
|Incubation Time||30 days|
|Results||Based on this diet,we induced chemical damage-induced NASH and biliary NASH, and on the NASH model we examined the potential efficacy of SR9243. As shown by Masson trichrome staining of liver tissue (Figure 1), we clearly observed from the pathological point of view, BDL significantly exacerbated liver fibrosis in both the control diet and HC diet group.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO <1 mg/mL
Water <1 mg/mL
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis.
Flaveny CA, et.al. Cancer Cell. 2015 Jul 13;28(1):42-56. PMID: 26120082.
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T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of ~ 50 nM.
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