| Cat.No. | Name | Information |
|---|---|---|
| M9354 | SR9238 | SR9238 is a liver X receptor (LXR) inverse agonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ, respectively. |
| M6768 | GSK2033 | GSK2033 is a potent LXR antagonist. |
| M1929 | GW3965 hydrochloride | GW3965 hydrochloride is a selective, orally active non-steroidal synthetic liver X receptor (LXR) agonist. |
| M54822 | Rovazolac | Rovazolac is a liver x receptor (LXR) modulator, which can be used in the study of immune system disorders and atopic dermatitis. |
| M29748 | GSK3987 | GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation. |
| M21744 | AZ876 | AZ876 is a novel, potent and high-affinity LXR agonist. AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling. |
| M19003 | Taraxasterol | Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. |
| M10627 | RGX-104 hydrochloride | RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. |
| M10621 | Iristectorigenin B | Iristectorigenin B is a liver X receptor (LXR) modulator, which stimulates the transcriptional activity of both LXR-α and LXR-β. |
| M10589 | RGX-104 | RGX-104, also known as SB 742881, is a liver X receptor beta (LXR) agonist with potential immunomodulating and antineoplastic activities. |
| M10138 | Yamogenin | Yamogenin (Diosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. |
| M6087 | LXR-623 | LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier. |
| M4874 | SR9243 | SR9243 is a potent and selective LXR inverse agonist. |
| M2204 | T0901317 | T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of 20~50 nM. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. |
| M42491 | GW6340 | GW6340 is an intestinal-specific LXR agonist. |
| M40968 | Larsucosterol | Larsucosterol is an endogenous sulfated oxysterol and a potent hepatic X receptor (LXR) and DNA methylase (DNMTS) antagonist that regulates endogenous lipogenesis as well as inhibits cholesterol biosynthesis by lowering mRNA levels and inhibiting SREBP-1 activation. May be used in studies related to psoriasis. |
| M30137 | 24(S)-Hydroxycholesterol | 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators. |
| M30052 | GW3965 | GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively. |
| M14461 | BMS-779788 | BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ. |
| M8744 | IMB-808 | IMB-808 is a potent Liver X receptor α and β (LXRα/β) partial dual agonist that promotes expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1), and associated with cholesterol metabolism pathway in multiple cell lines (including ApoE). |
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