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Liver X Receptor Liver X Receptor

Cat.No.  Name Information
M6768 GSK2033 GSK2033 is a potent LXR antagonist.
M1929 GW3965 hydrochloride GW3965 hydrochloride is a selective, orally active non-steroidal synthetic liver X receptor (LXR) agonist.
M10627 RGX-104 hydrochloride RGX-104 hydrochloride is a small-molecule LXR (liver X receptor) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.
M10621 Iristectorigenin B Iristectorigenin B is a liver X receptor (LXR) modulator, which stimulates the transcriptional activity of both LXR-α and LXR-β.
M10138 Yamogenin Yamogenin (Diosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay.
M9354 SR9238 SR9238 is a liver X receptor (LXR) inverse agonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ, respectively.
M6087 LXR-623 LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
M4874 SR9243 SR9243 is a potent and selective LXR inverse agonist.
M2204 T0901317 T0901317 is a potent and selective agonist for both LXRα and LXRβ with an EC50 of ~ 50 nM.
M42491 GW6340 GW6340 is an intestinal-specific LXR agonist.
M40968 Larsucosterol Larsucosterol is an endogenous sulfated oxysterol and a potent hepatic X receptor (LXR) and DNA methylase (DNMTS) antagonist that regulates endogenous lipogenesis as well as inhibits cholesterol biosynthesis by lowering mRNA levels and inhibiting SREBP-1 activation. May be used in studies related to psoriasis.
M30137 24(S)-Hydroxycholesterol 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.
M30052 GW3965  GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively.
M29748 GSK3987  GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation.
M14461 BMS-779788 BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.
M10589 RGX-104 RGX-104, also known as SB 742881, is a liver X receptor beta (LXR) agonist with potential immunomodulating and antineoplastic activities.
M8744 IMB-808 IMB-808 is a potent Liver X receptor α and β (LXRα/β) partial dual agonist that promotes expression of genes related to reverse cholesterol transport (including ABCA1 and ABCG1), and associated with cholesterol metabolism pathway in multiple cell lines (including ApoE).
M8590 TFCA TFCA is a Liver X receptor α (LXRα) antagonist that reduces lipid accumulation and fatty liver in mice.




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