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Solithromycin

Cat. No. M6171
Solithromycin Structure
Synonym:

CEM-101; OP-1068

Size Price Availability Quantity
5mg USD 200 In stock
10mg USD 350 In stock
25mg USD 800 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Antibacterial Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. The mean 50% inhibitory concentrations (IC50s) for Solithromycin inhibition of cell viability, protein synthesis, and growth rate were 7.5, 40, and 125 ng/ml for Streptococcus pneumoniae,Staphylococcus aureus, and Haemophilus influenzae, respectively.

Protocol
Cell Experiment
Cell lines S. aureus cells
Preparation method For S. pneumoniae, 12 9-ml cultures of cells comprised of one control set and one set with solithromycin at 7.5 ng/ml were grown to a Klett reading of 15.
Concentrations 7.5 ng/ml
Incubation time 15-min
Animal Experiment
Animal models donor mic
Formulation DMSO
Dosages 100 mg/kg
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 845.01
Formula C43H65FN5O10
CAS Number 760981-83-7
Purity >99%
Solubility 32 mg/mL in DMSO
Storage at -20°C
References

Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.
Rodgers W, et al. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-7. PMID: 23318809.

In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.
Wittlin S, et al. Antimicrob Agents Chemother. 2012 Feb;56(2):703-7. PMID: 22083475.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Solithromycin, CEM-101; OP-1068 supplier, inhibitors

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