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Solithromycin

Cat. No. M6171

All AbMole products are for research use only, cannot be used for human consumption.

Solithromycin Structure
Synonym:

CEM-101; OP-1068

Size Price Availability Quantity
5mg USD 65  USD65 In stock
10mg USD 110  USD110 In stock
25mg USD 220  USD220 In stock
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Quality Control & Documentation
Biological Activity

Antibacterial Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. The mean 50% inhibitory concentrations (IC50s) for Solithromycin inhibition of cell viability, protein synthesis, and growth rate were 7.5, 40, and 125 ng/ml for Streptococcus pneumoniae,Staphylococcus aureus, and Haemophilus influenzae, respectively.

Protocol (for reference only)
Cell Experiment
Cell lines S. aureus cells
Preparation method For S. pneumoniae, 12 9-ml cultures of cells comprised of one control set and one set with solithromycin at 7.5 ng/ml were grown to a Klett reading of 15.
Concentrations 7.5 ng/ml
Incubation time 15-min
Animal Experiment
Animal models donor mic
Formulation DMSO
Dosages 100 mg/kg
Administration i.v.
Chemical Information
Molecular Weight 845.01
Formula C43H65FN5O10
CAS Number 760981-83-7
Form Solid
Solubility (25°C) 32 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rodgers W, et al. Antimicrob Agents Chemother. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.

[2] Wittlin S, et al. Antimicrob Agents Chemother. In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species.

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Keywords: Solithromycin, CEM-101; OP-1068 supplier, Antibiotic, inhibitors, activators

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