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Solcitinib

Cat. No. M7551
Solcitinib Structure
Synonym:

GSK-2586184; GLPG-0778

Size Price Availability
5mg USD 110 4-7 Days
10mg USD 145 4-7 Days
50mg USD 405 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Solcitinib is a selective Janus kinase 1 (JAK1) inhibitor, for the treatment of psoriasis, lupus, and ulcerative colitis. Targer: JAK1

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 389.45
Formula C22H23N5O2
CAS Number 1206163-45-2
Purity >98%
Solubility 20 mg/mL in DMSO
Storage at -20°C
References

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome and the Rheumatologist.
Adwan MH Curr Rheumatol Rep. 2017 Jan;19(1):3. PMID: 28138822.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Solcitinib, GSK-2586184; GLPG-0778 supplier, JAK, inhibitors

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