Solabegron (GW 427353) is a selective agonist of β3 adrenergic receptor (β3-AR). The EC50 value of Solabegron was 22 nM in Chinese hamster ovarian cells. It can be used to study overactive bladder and irritable bowel syndrome.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO ≥ 60 mg/mL|
|Storage||4°C , protect from light , dry , sealed|
 April B M Grudell, et al. Am J Physiol Gastrointest Liver Physiol. Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health
 Alexandra Hicks, et al. J Pharmacol Exp Ther. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog
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