Sodium oxamate is a competitive LDHA (actate dehydrogenase A) inhibitor, it inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water ≥ 20 mg/mL|
|Storage||2-8°C, dry, protect from light, sealed|
Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-tumor Effect of Gemcitabine
Yan Guo, et al. Int J Biol Sci. 2019 Jul 3;15(9):1771-1786. PMID: 31523182.
Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells
Hiroyuki Muramatsu, et al. Oncol Rep. 2019 Jul;42(1):224-230. PMID: 31180564.
Mechanistic Analysis of Fluorescence Quenching of Reduced Nicotinamide Adenine Dinucleotide by Oxamate in Lactate Dehydrogenase Ternary Complexes
Huo-Lei Peng, et al. Photochem Photobiol. 2017 Oct;93(5):1193-1203. PMID: 28391608.
Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells
Xiaoming Zhai, et al. Oncol Rep. 2013 Dec;30(6):2983-91. PMID: 24064966.
Thrombin is a trypsin-like allosteric serine protease.
Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and directly inhibits the OGA-stimulated production of H2O2 by soybean cells, even in the absence of other fungal components.
5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), with IC50 of 420 nM and Kd of 170 nM.
Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia.
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