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Sodium oxamate

Cat. No. M9783
Sodium oxamate Structure
Synonym:

Oxamic acid sodium salt

Size Price Availability Quantity
5g USD 100 In stock
10g USD 200 In stock
25g USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sodium oxamate is a competitive LDHA (actate dehydrogenase A) inhibitor, it inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 111.03
Formula C2H2NNaO3
CAS Number 565-73-1
Purity >98%
Solubility Water ≥ 20 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

Combined Aberrant Expression of NDRG2 and LDHA Predicts Hepatocellular Carcinoma Prognosis and Mediates the Anti-tumor Effect of Gemcitabine
Yan Guo, et al. Int J Biol Sci. 2019 Jul 3;15(9):1771-1786. PMID: 31523182.

Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells
Hiroyuki Muramatsu, et al. Oncol Rep. 2019 Jul;42(1):224-230. PMID: 31180564.

Mechanistic Analysis of Fluorescence Quenching of Reduced Nicotinamide Adenine Dinucleotide by Oxamate in Lactate Dehydrogenase Ternary Complexes
Huo-Lei Peng, et al. Photochem Photobiol. 2017 Oct;93(5):1193-1203. PMID: 28391608.

Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells
Xiaoming Zhai, et al. Oncol Rep. 2013 Dec;30(6):2983-91. PMID: 24064966.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sodium oxamate, Oxamic acid sodium salt supplier, inhibitors

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