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Sodium orthovanadate

Cat. No. M5161

Sodium orthovanadate Structure
Size Price Availability Quantity
5g USD 60 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. Sodium orthovanadate rescues cells from delayed neuronal death in the hippocampal CA1 region. The neuroprotective effects of Sodium orthovanadate and IGF-1 are associated with preventing decreased Akt-Ser-473 phosphorylation in the CA1 region observed immediately after reperfusion. Sodium orthovanadate inhibits ASK1 through the PI3-K/Akt-dependent pathway. Sodium orthovanadate rescues cells from ischemia/reperfusion injuries in a rat model of myocardial ischemic infarction. Sodium orthovanadate treatment also ameliorates contractile dysfunction of the left ventricle 72 hours after reperfusion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 183.91
Formula Na3O4V
CAS Number 13721-39-6
Purity >99%
Solubility Water 35 mg/mL
Storage at -20°C
References

Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B.
Wu Y, et al. Acta Pharmacol Sin. 2005 Mar;26(3):345-52. PMID: 15715932.

Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis.
Takada Y, et al. J Pharmacol Exp Ther. 2004 Dec;311(3):1249-55. PMID: 15292457.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sodium orthovanadate supplier, ATPase, inhibitors

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