SKF38393 hydrochloride is a selective agonist of the D1DR (dopamine D1 receptor). SKF-38393 HCl is an activator of D5DR. SKF38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. SKF38393 HCl has stimulant and anorectic effects. SKF-38393 hydrochloride enhances the frequency of mEPSCs in a concentration-dependent manner.
|Cell lines||MCF-7, MDA-MB231 and MCF-10 cells|
|Preparation method||Examine the effects of a specific dopamine agonist, SKF 38393, against MCF-7 cells. MDA-MB231 and MCF-10 cells were used as negative controls. The breast cancer in vitro screening procedure involved the plating of MCF-7, MDA-MB231 and MCF-10 cells in a 96-well plate assay. After 1 day, the cells were exposed to SKF 38393 for 2 days and cell growth was determined by the Alamar blue dye reagent method. The optical density data was analyzed and IC50 values determined. The results indicated that SKF 38393 caused a significant decrease in proliferation of MCF-7 cells. The IC50 value was 0.1 +/- 0.03 mu M. The results also indicated no significant effect on MDA-MB231 and MCF-10 cells.|
|Incubation time||2 days|
|Animal models||Male Wistar rats|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO: ≥ 30 mg/mL|
Role of the basolateral amygdala dopamine receptors in arachidonylcyclopropylamide-induced fear learning deficits.
Nasehi M, et al. Psychopharmacology (Berl). 2016 Jan;233(2):213-24. PMID: 26546370.
Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.
Reichenbach N, et al. Proteome Sci. 2015 Mar 18;13:13. PMID: 25852303.
Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat.
Amico F, et al. Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. PMID: 17900561.
Dopamine D1/D5 receptor activation modulates a persistent sodium current in rat prefrontal cortical neurons in vitro.
Gorelova NA, et al. J Neurophysiol. 2000 Jul;84(1):75-87. PMID: 10899185.
Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction autoradiography.
Altar CA, et al. J Neurosci. 1987 Jan;7(1):213-22. PMID: 2949066.
|Related Dopamine Receptor Products|
SCH23390 is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively).
MPTP hcl is a compound to the neurotoxin MPP+ which causes permanent symptoms of Parkinson's disease.
|SCH 23390 hydrochloride
SCH 23390 hydrochloride is a standard selective D 1-like antagonist; also 5-HT 2C and 5-HT 1C agonist and K ir3 channel blocker.
Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.