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SKF38393 HCl

Cat. No. M9022
SKF38393 HCl Structure
Synonym:

SKF-38393A

Size Price Availability Quantity
25mg USD 50  USD50 In stock
50mg USD 80  USD80 In stock
100mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

SKF38393 hydrochloride is a selective agonist of the D1DR (dopamine D1 receptor). SKF-38393 HCl is an activator of D5DR. SKF38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. SKF38393 HCl has stimulant and anorectic effects. SKF-38393 hydrochloride enhances the frequency of mEPSCs in a concentration-dependent manner.

Protocol (for reference only)
Cell Experiment
Cell lines MCF-7, MDA-MB231 and MCF-10 cells
Preparation method Examine the effects of a specific dopamine agonist, SKF 38393, against MCF-7 cells. MDA-MB231 and MCF-10 cells were used as negative controls. The breast cancer in vitro screening procedure involved the plating of MCF-7, MDA-MB231 and MCF-10 cells in a 96-well plate assay. After 1 day, the cells were exposed to SKF 38393 for 2 days and cell growth was determined by the Alamar blue dye reagent method. The optical density data was analyzed and IC50 values determined. The results indicated that SKF 38393 caused a significant decrease in proliferation of MCF-7 cells. The IC50 value was 0.1 +/- 0.03 mu M. The results also indicated no significant effect on MDA-MB231 and MCF-10 cells.
Concentrations
Incubation time 2 days
Animal Experiment
Animal models Male Wistar rats
Formulation saline
Dosages 6 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 291.77
Formula C16H17NO2.HCl
CAS Number 62717-42-4
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nasehi M, et al. Psychopharmacology (Berl). Role of the basolateral amygdala dopamine receptors in arachidonylcyclopropylamide-induced fear learning deficits.

[2] Reichenbach N, et al. Proteome Sci. Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.

[3] Amico F, et al. Eur J Pharmacol. Performance- and task-dependent effects of the dopamine D1/D5 receptor agonist SKF 38393 on learning and memory in the rat.

[4] Gorelova NA, et al. J Neurophysiol. Dopamine D1/D5 receptor activation modulates a persistent sodium current in rat prefrontal cortical neurons in vitro.

[5] Altar CA, et al. J Neurosci. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction autoradiography.

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