Free shipping on all orders over $ 500

SGC-CBP30

Cat. No. M9141
SGC-CBP30 Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 175 In stock
5mg USD 157 In stock
10mg USD 183 In stock
25mg USD 437 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. It has 40-fold selectivity for CBP over BRD4. SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells as a CREBBP/EP300-selective chemical probe.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 509.04
Formula C28H33ClN4O3
CAS Number 1613695-14-9
Purity 99.62%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo.
Tao J, et al. Biomed Pharmacother. 2018 Oct;106:1727-1733. PMID: 30119248.

Activity of bromodomain protein inhibitors/binders against asexual-stage Plasmodium falciparum parasites.
Chua MJ, et al. Int J Parasitol Drugs Drug Resist. 2018 Aug;8(2):189-193. PMID: 29631126.

Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer.
Xiang Q, et al. Eur J Med Chem. 2018 Mar 10;147:238-252. PMID: 29448139.

Related Epigenetic Reader Domain Products
AZD5153

AZD5153 is a potent bivalent triazolopyridazine based Bromodomain and Extraterminal (BET) Inhibitor, with IC50 value of 5 nM.

MS417

MS417 (also known as GTPL7512) is a potent and selective BRD4 inhibitor, which binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30 and 46 nM, respectively.

FL-411

FL-411 is a selective BRD4 inhibitor.

dBET6

dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM.

dBET1

dBET1 is a potent BRD4 protein degrader with an EC50 of 430 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SGC-CBP30 supplier, Epigenetic Reader Domain, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.