Catalog

Epigenetic Reader Domain Epigenetic Reader Domain

Inhibitors

Cat.No.	Name	Information
M9238	dBET6	dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM.
M9237	dBET1	dBET1 is a potent BRD4 protein degrader with an EC50 of 430 nM.
M9218	ABBV-744	ABBV-744 is a BDII-selective BET bromodomain inhibitor that is used in the research of AML and metastic castration-resistant prostate cancer.
M9152	CPI-637	CPI-637 is a potent and selective CBP/EP300 bromodomains inhibitor with IC50 of 0.03±0.01μM and 11.0±0.6 μM for CBP/EP300 and BRD4, respectively.
M9146	GSK1324726A	GSK1324726A (I-BET726) is a highly selective inhibitor of BET family proteins with IC50 of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively.
M9144	PFI-3	PFI-3 is a selective chemical probe for SMARCA bromodomains, including SMARCA2, SMARCA4 and PB1(5) bromodomains with a Kd of 89 nM.
M9141	SGC-CBP30	SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively.
M9105	ARV-771	ARV-771 is a small-molecule pan-BET degrader with Kd values of 4.7, 7.6, 7.6 nM against BRD2, BRD3 and BRD4, respectively.
M9100	PLX51107	PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively.
M9026	AZD-5153 HNT salt	AZD-5153 HNT salt is a potent, selective and orally available BET/BRD4 bromodomain inhibitor, disrupts BRD4 with an IC50 of 1.7 nM.
M8931	BI-7273	BI-7273 is a potent and selective BRD9 inhibitor with IC50s of 19 nM and 117 nM for BRD9 and BRD7, respectively.
M6206	ARV-825	ARV-825 is a BRD4 Inhibitor based on PROTAC technology. ARV-825 shows affinity to BD1 and BD2 of BRD4 with Kds of 90 and 28 nM, respectively.
M6118	666-15	666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM.
M6096	JQ-1 carboxylic acid	(+)-JQ1 carboxylic acid is the carboxylic acid form of (+)-JQ1 for derivative synthesis.
M6083	AZD9496	AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
M5271	GSK6853	GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.
M5258	Mivebresib	Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4)
M5064	PFI 4	PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.
M4909	GSK2801	GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.
M3526	CPI-203	CPI-203 is a novel potent, selective BET bromodomain inhibitor with IC50 of 37 nM for BRD4.
M2932	PFI-1	PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.
M2903	OTX015	OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4.
M2219	RVX-208	RVX-208 is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2.
M2202	CPI-0610	CPI-0610 is a novel BET protein bromodomain inhibitor.
M2190	I-BET-762	I-BET-762 (GSK525762) is a selective small molecule BET inhibitor.
M2167	(+)-JQ1	(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M2096	GSK1210151A	GSK1210151A (I-BET151) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively.

Signaling Pathways

Product Type

Epigenetic Reader Domain Epigenetic Reader Domain

Get to Know Us

Customer Support

Resources

Contact Us