Catalog

Epigenetic Reader Domain Epigenetic Reader Domain

Inhibitors

Cat.No.	Name	Information
M5271	GSK6853	GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.
M5258	Mivebresib	Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4)
M5064	PFI 4	PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.
M4909	GSK2801	GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.
M3526	CPI-203	CPI-203 is a novel potent, selective BET bromodomain inhibitor with IC50 of 37 nM for BRD4.
M2932	PFI-1	PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.
M2903	OTX015	OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4.
M2219	RVX-208	RVX-208 is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2.
M2202	CPI-0610	CPI-0610 is a novel BET protein bromodomain inhibitor.
M2190	I-BET-762	I-BET-762 (GSK525762) is a selective small molecule BET inhibitor.
M2167	(+)-JQ1	(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M2096	GSK1210151A	GSK1210151A (I-BET151) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively.