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  Catalog
Abmole Inhibitor Catalog 2017

Epigenetic Reader Domain Epigenetic Reader Domain

Inhibitors

Cat.No.  Name Information
M6083 AZD9496 AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.
M5271 GSK6853 GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.
M5258 Mivebresib Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4)
M5064 PFI 4 PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.
M4909 GSK2801 GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.
M3526 CPI-203 CPI-203 is a novel potent, selective BET bromodomain inhibitor with IC50 of 37 nM for BRD4.
M2932 PFI-1 PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.
M2903 OTX015 OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4.
M2219 RVX-208 RVX-208 is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2.
M2202 CPI-0610 CPI-0610 is a novel BET protein bromodomain inhibitor.
M2190 I-BET-762 I-BET-762 (GSK525762) is a selective small molecule BET inhibitor.
M2167 (+)-JQ1 (+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.
M2096 GSK1210151A GSK1210151A (I-BET151) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively.


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