|M6083||AZD9496||AZD9496 is an oral estrogen receptor inhibitor that blocks the growth of ER-positive and ESR1 mutant breast tumours in preclinical models.|
|M5271||GSK6853||GSK6853 is a selective benzimidazolone BRPF1 inhibitor with pIC50 of 8.1(TR-FRET) showing greater than 1600-fold selectivity over all other bromodomains tested.|
|M5258||Mivebresib||Mivebresib(ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4)|
|M5064||PFI 4||PFI-4 is a potent and selective BRPF1 bromodomain inhibitor with IC50 of 80 nM.|
|M4909||GSK2801||GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively.|
|M3526||CPI-203||CPI-203 is a novel potent, selective BET bromodomain inhibitor with IC50 of 37 nM for BRD4.|
|M2932||PFI-1||PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM.|
|M2903||OTX015||OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4.|
|M2219||RVX-208||RVX-208 is a first-in-class, small molecule inhibitor of BET bromodomain with IC50 of 0.51 μM for BD2.|
|M2202||CPI-0610||CPI-0610 is a novel BET protein bromodomain inhibitor.|
|M2190||I-BET-762||I-BET-762 (GSK525762) is a selective small molecule BET inhibitor.|
|M2167||(+)-JQ1||(+)-JQ1 is a potent, high affinity, selective BET bromodomain inhibitor.|
|M2096||GSK1210151A||GSK1210151A (I-BET151) is an inhibitor of the BET family with IC50 of 0.5 μM, 0.25 μM and 0.79 μM for BRD2, BRD3 and BRD4, respectively.|
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