Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Rats, Mice |
| Formulation | In water or the mixture (% by volume), 5% ethanol + 5% Emulphor-EL-620 + 90%normal saline. |
| Dosages | |
| Administration | i.p. |
| Molecular Weight | 342.69 |
| Formula | C17H17Cl2N.HCl |
| CAS Number | 79559-97-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Andrea Cipriani, et al. Sertraline versus other antidepressive agents for depression
[5] C Lindsay DeVane, et al. Clinical pharmacokinetics of sertraline
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