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SEA 0400

Cat. No. M7288
SEA 0400 Structure
Size Price Availability
5mg USD 210  USD210 4-7 Days
10mg USD 320  USD320 4-7 Days
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Quality Control & Documentation
Biological Activity

SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

Chemical Information
Molecular Weight 371.38
Formula C21H19F2NO3
CAS Number 223104-29-8
Form Solid
Solubility (25°C) DMSO 37.14 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dueweke, et al. Antimicrob Agents Chemother. U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication.

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  Catalog
Abmole Inhibitor Catalog




Keywords: SEA 0400 supplier, Sodium Channel, inhibitors, activators


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