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SCH 23390 hydrochloride

Cat. No. M7279
SCH 23390 hydrochloride Structure
Synonym:

R-(+)-SCH23390 hydrochloride

Size Price Availability
10mg USD 145 1-2 Weeks
25mg USD 330 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). SCH 23390 hydrochloride is also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). SCH 23390 hydrochloride blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors. 

The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 324.24
Formula C17H18ClNO.HCl
CAS Number 125941-87-9
Purity >98%
Solubility Water 30 mg/mL (with gentle warming)
Storage at -20°C
References

AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography.
Dopke, et al. J Pharmacol Exp Ther. 1995;274: 562. PMID: 7616446.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SCH 23390 hydrochloride, R-(+)-SCH23390 hydrochloride supplier, Dopamine Receptor, inhibitors

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