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Sanggenon B

Cat. No. M17311
Sanggenon B Structure
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Biological Activity

Sanggenon B

Chemical Information
CAS Number 81381-67-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wonmin Ko, et al. Molecules. Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells

[2] Yong-Xiang Wu, et al. Nat Prod Res. Anti-inflammatory effects of mulberry ( Morus alba L.) root bark and its active compounds

[3] Liangjin Xu, et al. Nat Prod Res. Phenolic compounds isolated from Morus nigra and their α-glucosidase inhibitory activities

[4] Xiao Hu, et al. J Asian Nat Prod Res. Isoprenylated phenolic compounds with tyrosinase inhibition from Morus nigra

[5] Nguyen Tien Dat, et al. Immunopharmacol Immunotoxicol. Sanggenon C and O inhibit NO production, iNOS expression and NF-κB activation in LPS-induced RAW264.7 cells

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