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S107

Cat. No. M9272
S107 Structure
Synonym:

S107 free base

Size Price Availability Quantity
10mM*1mL In DMSO USD 120 In stock
2mg USD 95 In stock
5mg USD 110 In stock
10mg USD 175 In stock
25mg USD 360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

S107 binds RyR1 and enhances the binding affinity of calstabin-1. S107 inhibits Ca leak from the sarcoplasmic reticulum (SR). S107 increases FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. S107 can reverse the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 209.31
Formula C11H15NOS
CAS Number 927871-76-9
Purity >98%
Solubility DMSO: ≥ 30 mg/mL
Storage at -20°C
References

Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107.
Mei Y, et al. PLoS One. 2013;8(1):e54208. PMID: 23349825.

Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.
Lehnart SE, et al. J Clin Invest. 2008 Jun;118(6):2230-45. PMID: 18483626.

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Keywords: S107, S107 free base supplier, inhibitors

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