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S107

Cat. No. M9272
S107 Structure
Synonym:

S107 free base

Size Price Availability Quantity
10mM*1mL USD 120  USD120 In stock
5mg USD 110  USD110 In stock
10mg USD 175  USD175 In stock
25mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

S107 binds RyR1 and enhances the binding affinity of calstabin-1. S107 inhibits Ca leak from the sarcoplasmic reticulum (SR). S107 increases FKBP12 binding to RyR1 in SR vesicles in the presence of reduced glutathione and the NO-donor NOC12, with no effect in the presence of oxidized glutathione. S107 can reverse the harmful effects of redox active species on SR Ca2+ release in skeletal muscle by binding to RyR1 low affinity sites.

Chemical Information
Molecular Weight 209.31
Formula C11H15NOS
CAS Number 927871-76-9
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mei Y, et al. PLoS One. Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107.

[2] Lehnart SE, et al. J Clin Invest. Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.

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