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S(-)-Propranolol hydrochloride

Cat. No. M20993
S(-)-Propranolol hydrochloride Structure
Synonym:

Hemangeol, Inderal

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(S)-(-)-Propranolol hydrochloride, the active enantiomer of propranolol, is a β-Adrenoceptor (β-Adrenergic Receptor) antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 295.8
Formula C16H22ClNO2
CAS Number 4199-10-4
Purity >99%
Solubility DMSO 59 mg/mL
Water 59 mg/mL
Storage at -20°C
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Keywords: S(-)-Propranolol hydrochloride, Hemangeol, Inderal supplier, Adrenergic Receptor, inhibitors

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