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(S)-(-)-BAY K 8644

Cat. No. M5077
(S)-(-)-BAY K 8644 Structure
Synonym:

(S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644

Size Price Availability Quantity
10mM*1mL in DMSO USD 166  USD166 In stock
5mg USD 153  USD153 In stock
10mg USD 197  USD197 In stock
50mg USD 831  USD831 In stock
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Quality Control & Documentation
Biological Activity

(S)-Bay K 8644 (100 nM) increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked further stimulation by 1 microM FPL 64176.(-)-S-Bay K 8644 enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or (+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity.

Chemical Information
Molecular Weight 356.3
Formula C16H15F3N2O4
CAS Number 98625-26-4
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rump AF,et.al. Gen Pharmacol. Influence of (-)-S-Bay K 8644, (+/-)-Bay W 5035 and (+/-)-Bay T 5006 on hemodynamics and FITC-dextran 3 elution kinetics in isolated rat hearts.

[2] Rampe D,et.al. Mol Pharmacol. Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle.

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Keywords: (S)-(-)-BAY K 8644, (S)-(-)-Bay-K-8644; (-)-BAY-R-5417; (-)-BAY-K-8644 supplier, Calcium Channel, inhibitors, activators

 
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