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S 38093

Cat. No. M9290
S 38093 Structure
Synonym:

S38093

Size Price Availability Quantity
10mM*1mL In DMSO USD 220 In stock
2mg USD 140 In stock
5mg USD 210 In stock
10mg USD 320 In stock
25mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

In cellular models, S 38093 was able to antagonize mice H3 receptors (KB=0.65µM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11µM). 

In vivo, S 38093 (0.3 and 3 mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. In mice, S 38093 significantly increases ex vivo N-tele-Methylhistamine cerebral levels from 3 mg/kg p.o. and antagonized R-α-Methylhistamine-induced dipsogenia from 10 mg/kg i.p..

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 288.38
Formula C17H24N2O2
CAS Number 862896-30-8
Purity >98%
Solubility DMSO: ≥ 9 mg/mL (Need warming and ultrasonic)
Storage at -20°C
References

Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
Chaumette T, et al. Eur J Pain. 2018 Jan;22(1):127-141. PMID: 28877402.

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.
Sors A, et al. Eur J Pharmacol. 2017 May 15;803:11-23. PMID: 28336400.

S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice.
Guilloux JP, et al. Sci Rep. 2017 Feb 20;7:42946. PMID: 28218311.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: S 38093, S38093 supplier, Histamine Receptor, inhibitors

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