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RU 58668 is a pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.
| Molecular Weight | 658.76 |
| Formula | C34H43F5O5S |
| CAS Number | 151555-47-4 |
| Solubility (25°C) | DMSO 65.88 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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