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Rimonabant Hydrochloride

Cat. No. M7325
Rimonabant Hydrochloride Structure
Synonym:

SR 141716A; SR 151716A

Size Price Availability Quantity
10mg USD 63  USD70 In stock
50mg USD 216  USD240 In stock
100mg USD 315  USD350 In stock
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Quality Control
Biological Activity

Rimonabant Hydrochloride (SR 141716A) is a potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Rimonabant Hydrochloride also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (IC50 = 48 nM). Rimonabant Hydrochloride displays no activity at CB2 receptors. Rimonabant Hydrochloride (SR 141716A) reduces food intake and body weight in orally dosed non-obese Wistar rats.

Product Citations
Customer Product Validations & Biological Datas
Source Neuron (2020 Feb). Figure 3. SR 141716A (Abmole Bioscience)
Method sIPSC assay
Cell Lines mice
Concentrations 10 μM
Incubation Time 1h
Results Inhibiting CB1R with SR at ZT0 increased inhibitory transmission to ZT12 levels, while SR had no effect at ZT12.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 500.25
Formula C22H21Cl3N4O.HCl
CAS Number 158681-13-1
Purity 99.62%
Solubility DMSO 25 mg/mL
Storage at -20°C
References

Selective antagonism of the anticonvulsant effects of felbamate by glycine.
Coffin, et al. Eur J Pharmacol. 1994;256: R9. PMID: 8050461.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rimonabant Hydrochloride, SR 141716A; SR 151716A supplier, Cannabinoid, inhibitors

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