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Rebaudioside B

Cat. No. M16453
Rebaudioside B Structure
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Biological Activity

Rebaudioside B

Chemical Information
CAS Number 58543-17-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Silvia Tavarini, et al. Molecules. Health-Promoting Compounds in Stevia: The Effect of Mycorrhizal Symbiosis, Phosphorus Supply and Harvest Time

[2] Jinping Dong, et al. Food Chem. Characterization of a new hemihydrate rebaudioside B crystal having lower aqueous solubility

[3] Shao-Shan Zhang, et al. Phytochemistry. Mutations in the uridine diphosphate glucosyltransferase 76G1 gene result in different contents of the major steviol glycosides in Stevia rebaudiana

[4] Sidd Purkayastha, et al. Regul Toxicol Pharmacol. In vitro metabolism of rebaudioside B, D, and M under anaerobic conditions: comparison with rebaudioside A

[5] Indra Prakash, et al. Int J Mol Sci. Catalytic hydrogenation of the sweet principles of Stevia rebaudiana, Rebaudioside B, Rebaudioside C, and Rebaudioside D and sensory evaluation of their reduced derivatives

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