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Razaxaban hydrochloride

Cat. No. M7663

All AbMole products are for research use only, cannot be used for human consumption.

Razaxaban hydrochloride Structure

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Quality Control & Documentation
Biological Activity

Razaxaban is an orally available, potent and specific coagulation factor Xa inhibitor that reduces thrombus and fibrin formation. Razaxaban exhibits potent antithrombotic efficacy in animal models and in patients with deep vein thrombosis.

Chemical Information
Molecular Weight 564.92
Formula C24H20F4N8O2 · HCl
CAS Number 405940-76-3
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Donglu Zhang, et al. Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs

[2] Pancras C Wong, et al. Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits

[3] Mimi L Quan, et al. Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor

[4] Bruce L Davidson. Preparing for the new anticoagulants

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Keywords: Razaxaban hydrochloride supplier, inhibitors, activators

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